Pyrimidine-indole hybrid Catalog No.:M34537-C 8S)-3-[(4-fluorophenyl)methyl]-6-hydroxy-4-oxo-3-azatricyclo[6

8S)-3-[(4-fluorophenyl)methyl]-6-hydroxy-4-oxo-3-azatricyclo[6

Bulleyaconitine A is an analgesic and antiinflammatory drug isolated from Aconitum plants

12-pentaen-12-yl}oxy)propanamide

26(2):300-306

with an IC50 of 140 nM

Pyrimidine-indole hybrid Catalog No.:M34537-C 8S)-3-[(4-fluorophenyl)methyl]-6-hydroxy-4-oxo-3-azatricyclo[6Pyrimidine indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of tubulin. Pyrimidine indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule