Rofecoxib Size:Solid 2 mg Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2

Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2

Formula: C47H57ClFN7O8S

5) in any of the groups

Deltarasin was dosed to mice bearing Panc-Tu-I xenografts via intra-peritoneal (IP) injection at 10 mg/kg once or twice per day

InChiKey: SCKXBVLYWLLALY-CQRYCMKKSA-N

Rofecoxib Size:Solid 2 mg Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2Rofecoxib is a nonsteroidal anti inflammatory drug (NSAID) that has now been withdrawn over safety concerns. Rofecoxib exhibits anti inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of rofecoxib is believed to be due to inhibition of prostaglandin synthesis, via inhibition of cyclooxygenase 2 (COX 2). At therapeutic concentrations in humans, rofecoxib does not inhibit the cyclooxygenase 1 (COX 1) isoenzyme.