RGB-286638 Size:Solid 2 mg 3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol hydrochloride

3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol hydrochloride

also known as Nec-2

2017 May 4

α1B and α1A receptors respectively

01) compared with HFD/BARD mice

RGB-286638 Size:Solid 2 mg 3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol hydrochlorideRGB 286638 is a multitargeted cyclin dependent kinase inhibitor. RGB 286638 triggers P53 dependent and independent anti multiple myeloma activity through inhibition of transcriptional CDKs. GB 286638 treatment resulted in MM cytotoxicity in vitro associated with inhibition of MM tumor growth and prolonged survival in vivo. RGB 286638 displayed caspase dependent apoptosis in both wt p53 and mutant p53 cells that was closely associated with the