OF-1 - BRPF Bromodomain Inhibitor. CAS# 919973-83-4 Catalog No.:M60222-10S Smiles: C[C@H](NC(=O)CN1CCOCC1)C(=O)N[C@@H](CC1C=CC(=CC=1)OC)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)[C@]1(C)CO1

Smiles: C[C@H](NC(=O)CN1CCOCC1)C(=O)N[C@@H](CC1C=CC(=CC=1)OC)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)[C@]1(C)CO1

Jolkkonen J

IhERG inhibition by KB-R7943 exhibits both time- and voltage-dependence but shows no preference for inactivated over activated channels

is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM

HCT116 colon cancer cells

OF-1 - BRPF Bromodomain Inhibitor. CAS# 919973-83-4 Catalog No.:M60222-10S Smiles: C[C@H](NC(=O)CN1CCOCC1)C(=O)N[C@@H](CC1C=CC(=CC=1)OC)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)[C@]1(C)CO1OF 1, CAS No. 919973 83 4, is the potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor. It binds to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2. 4 mM (ITC). It has general >100 fold selectivity against other bromodomains (39 fold selectivity over BRD4). OF 1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 M and also