PF-00356231 hydrochloride inyl urea C[C@@H]1CC[C@]2(O[C@@H]1CC1=NC3=C(C(=CC=C3O1)NC)C([O-])=O)O[C@H]([C@H](C)C(=O)C1=CC=CN1)[C@H](C)C[C@H]2C

C[C@@H]1CC[C@]2(O[C@@H]1CC1=NC3=C(C(=CC=C3O1)NC)C([O-])=O)O[C@H]([C@H](C)C(=O)C1=CC=CN1)[C@H](C)C[C@H]2C

This leads to the cell's death via loss of intracellular elements

PubMed PMID: 20003343

2006 Oct 12

InChiKey: AXOJRQLKMVSHHZ-UHFFFAOYSA-N

PF-00356231 hydrochloride inyl urea C[C@@H]1CC[C@]2(O[C@@H]1CC1=NC3=C(C(=CC=C3O1)NC)C([O-])=O)O[C@H]([C@H](C)C(=O)C1=CC=CN1)[C@H](C)C[C@H]2CPF 00356231 hydrochloride is a specific, non peptidic, non zinc chelating ligand and inhibitor of matrix metalloproteinase MMP 12 (IC50=1. 4 M). PF 00356231 hydrochloride binds to MMP 12 and forms PF 00356231 MMP 12 complex. PF 00356231 hydrochloride shows potency against MMP 13, MMP 8, MMP 9, MMP 3 with IC50s of 0. 00065, 1. 7, 0. 98, 0. 39 M, respectively. Product information CAS Number: 820223 77 6 Molecular Weight: 464. 96 Formula: C25H21ClN2O3S