BML-277 nlafaxine CAS Number: 115550-35-1

CAS Number: 115550-35-1

2006 Oct 1

GSK2256098

5-triazine hydrochloride

CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)C3C=CC(O)=CC=3)C(=O)N2[C@H]1C([O-])=O

BML-277 nlafaxine CAS Number: 115550-35-1BML 277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML 277 protects T cells from apoptosis by controlling the response of p53 to radiation induced DNA breaks. ML 277 has IC50 = 15 nM; Ki = 37 nM. ML 277 shows 1000 fold greater selectivity for the Chk2 serine threonine kinase than for the Cdk1 B and CK1 kinases (for which IC50 = 12 M and 17 M, respectively). Product information CAS Number: 516480 79 8 Molecular Weight: