Gamma-glutamylcysteine TFA - CAS# 283159-88-6 Catalog No.:M12858-2 EX-527 was administered by intracerebroventricular

EX-527 was administered by intracerebroventricular injection to rats at 5-10 µg to increase hypothalamic acetyl-p53 levels by inhibiting hypothalamic SIRT1 activity (formulation: dissolved in DMSO in a total volume of 5 μL)

ZSTK474 also inhibits the phosphorylation of other downstream signaling components that are involved in regulating cell proliferation including FKHRL1

2-a]pyrimidin-3-yl]prop-2-enenitrile

CAS Number: 553-21-9

5)6)66-77-40-51(68)62-32-35-75-37-38-76-36-33-63-58(73)55(53(45-21-11-8-12-22-45)46-23-13-9-14-24-46)65-57(72)50-27-18-34-67(50)59(74)54(47-25-15-10-16-26-47)64-56(71)44(4)61-7/h8-9

Gamma-glutamylcysteine TFA - CAS# 283159-88-6 Catalog No.:M12858-2 EX-527 was administered by intracerebroventricularGamma glutamylcysteine ( Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma glutamylcysteine TFA also upregulates the level of the anti inflammatory cytokine IL 10 and reduces the levels of the pro inflammatory cytokines (TNF , IL 6, and IL 1). Gamma glutamylcysteine TFA attenuates the changes in metalloproteinase activity