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Z-DQMD-FMK 17517 is a known MAPK inhibitor

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Description

is a known MAPK inhibitor

Chemical Name: 2-amino-N-(7-methoxy-8-(3-morpholinopropoxy)-2

CAS Number: 1141777-14-1

CC1C2NC3C=CC=CC=3C=2C(C)=C2C=NC=CC=12

InChi: InChI=1S/C24H26ClF2N5O2/c1-14-10-21(31-30-14)29-20-7-6-18(26)19(28-20)12-24(23(33)34)8-9-32(15(2)11-24)13-16-4-3-5-17(25)22(16)27/h3-7

Z-DQMD-FMK 17517 is a known MAPK inhibitorInhibition of caspase 3 processing by Z DQMD FMK (Z Asp(OMe) Gln Met Asp(OMe) fluoromethylketone) did not restore cell number in the zinc deficient group, but resulted in processing of full length PKC to a 56 kDa fragment1. The inhibitory effect of specific caspase inhibitors (Z DQMD FMK, Z IETD FMK and Z LEHD FMK) suggests that the MG132 induced apoptotic cell death and depletion of GSH in SCLC cells are mediated by both activation of caspase 8 and

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