PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid CAS Number: 1675201-83-8

CAS Number: 1675201-83-8

Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells

cytokine production and autoantibody levels at well-tolerated doses

(2013) MBio

6(10):e26064

PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid CAS Number: 1675201-83-8PP242, CAS No. 1092351 67 1, is a highly potent, selective and ATP competitive mTORC1 mTORC2 inhibitor (IC50 = 8 nM). It has > 10 folds selectivity over the other PI 3K family kinases (IC50 0. 102 M, 0. 408 M, 1. 27 M, 1. 96 M and 2. 2 M for p110, DNA PK, p110, p110 and p110, respectively). Except some weak inhibitory activity against PKC, JAK2, PKCI, PKCII and RET (0. 05 0. 22 M), PP242 exhibits excellent selectivity over 215 other protein kinases.