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BX912 blocks PDK1/Akt signaling in tumor cells and suppresses the anchorage-dependent growth of a variety of tumor cell lines (such as PC-3 cells) in culture or induces apoptosis
Hodivala-Dilke K
126(10):1193-202
88 μM) suggests an ability to overcome drug resistance in ovarian cancer
DWN63831 was first reported in patent WO 2020024017
SBI-0640756 idotoxin TFA BX912 blocks PDK1/Akt signaling inSBI 0640756 (SBI 756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex. Product information CAS Number: 1821280 29 8 Molecular Weight: 404. 82 Formula: C23H14ClFN2O2 Chemical Name: 6 chloro 3 [(2E) 3 (5 fluoropyridin 3 yl)prop 2 enoyl] 4 phenyl 1,2 dihydroquinolin 2 one Smiles: O=C1NC2C=CC(Cl)=CC=2C(=C1C(=O) C=C C1C=NC=C(F)C=1)C1C=CC=CC=1 InChiKey: VVWGPQZBDQVQRC RMKNXTFCSA N InChi: InChI=1S C23H14ClFN2O2 c24 16 7 8 19 18(11 16)21(15 4 2 1 3 5
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