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Crenolanib treatment does not increase the cell surface expression of ABCB1
resulting from the CYP3A4/5-mediated catalysis of tamoxifen
also known as 25-hydroxy Vitamin D3
118(4):1289-1297
Deshpande AJ
FTI-277 Hydrochloride Size:Solid 10 mg Crenolanib treatment does not increaseFTI 277 is a peptide mimetic of the COOH terminal Cys Val Ile Met of K Ras4B that inhibited potently FTase in vitro (IC50 = 500 pM) and was highly selective for FTase over geranylgeranyltransferase I (GGTase I) (IC50 = 50 nM). FTI 277, the methyl ester derivative of FTI 276, was extremely potent (IC50 = 100 nM) at inhibiting H Ras, but not the geranylgeranylated Rap1A processing in whole cells. Product information CAS Number: 180977 34 8 Molecular
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