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5 nM and 303
Smiles: [O-][N@@+]12CCC[C@H]3CN4[C@H](CCCC4=O)[C@@H](CCC1)[C@@H]23
Formula: C17H15N5O2
CAS Number: 1314890-29-3
PubMed PMID: 21258765
Eg5 Inhibitor III - CAS# 863774-58-7 Catalog No.:M6537-2 5 nM and 303Eg5 Inhibitor III, CAS No. 863774 58 7, is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Eg5 Inhibitor III suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours. Product
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