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promoting its auto-ubiquitination and degradation by the proteasome
irreversible modification of GDP-bound recombinant KRAS G12C and suppresses ERK phosphorylation with an IC50 = 1 nM in the H358 cell line
Smiles: CNC(=O)C1C=CC(=CC=1)NC1=NC(NCC2=NC=CN=C2N(C)S(C)(=O)=O)=C(C=N1)C(F)(F)F
Formula: C24H24N4O5S
CAS Number: 980-71-2
Lovastatin ndolapril promoting its auto-ubiquitination and degradationLovastatin inhibits HMGCR, blocking the enzyme catalyzed transformation of 3 hydroxy 3 methylglutaryl CoA into mevalonate. Lovastatin is a statin natural product isolated from numerous sources including the Pleurotus ostreatus oyster mushroom, demonstrating hypocholesterolemic and antiproliferative properties. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts