BIBS 39 odoHoechst 33258 InChi: InChI=1S/C20H20O5/c1-11-12(2)20(14-4-6-16-18(8-14)24-10-22-16)25-19(11)13-3-5-15-17(7-13)23-9-21-15/h3-8

InChi: InChI=1S/C20H20O5/c1-11-12(2)20(14-4-6-16-18(8-14)24-10-22-16)25-19(11)13-3-5-15-17(7-13)23-9-21-15/h3-8

41(2):598-610

Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection

InChi: InChI=1S/C33H44O17/c1-42-18-6-13(4-5-17(18)47-32-27(40)25(38)23(36)21(9-34)48-32)29-15-11-46-30(16(15)12-45-29)14-7-19(43-2)31(20(8-14)44-3)50-33-28(41)26(39)24(37)22(10-35)49-33/h4-8

1221 and 4807 nM for Ramos cathepsin S

BIBS 39 odoHoechst 33258 InChi: InChI=1S/C20H20O5/c1-11-12(2)20(14-4-6-16-18(8-14)24-10-22-16)25-19(11)13-3-5-15-17(7-13)23-9-21-15/h3-8BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. Target: Angiotensin Receptorin vitro: BIBS 39 displaces [125I] AII from its specific binding sites with a Ki value of 29 7 nM for the AII subtype 1 (AT1) receptor and a Ki value of 480 110 nM for the AII subtype 2 (AT2) receptor. BIBS 222 shows a Ki value of 20 7 nM for the AT1 subtype and a Ki value of 730 170 nM for the AT2 subtype. BIBS 39 is 17 times more selective for the AT1