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8(9):1107-12
Formula: C18H29ClN2O
Formula: C12H14N4O2S
CAS Number: 258843-62-8
InChiKey: QIAVTDQTRFYXSD-WLHGVMLRSA-N
AN-2728 - CAS# 906673-24-3 Catalog No.:M10493-2 8(9):1107-12Crisaborole, also known as AN 2728, is a topically administered, boron containing, anti inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL 12, IL 23 and other cytokines. At the time of publication, three phase Ib clinical trials, a IIa trial and a IIb trial of AN 2728 in patients with psoriasis had been completed; the compound was also undergoing phase II development for atopic dermatitis, but no data