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TA 02 and SB203580 reduce the nuclear TCF/LEF-1 driven transcription of luciferase similar to DKK-1
Chemical Name: 4-carbamothioylphenyl 2-(6-methoxynaphthalen-2-yl)propanoate
InChi: InChI=1S/C24H32N6O3/c1-3-25-24(31)26-18-6-4-17(5-7-18)22-27-21-12-29(19-14-33-15-19)9-8-20(21)23(28-22)30-10-11-32-13-16(30)2/h4-7
and the IC50 value of the compound against CaM-KII is 10 μg/mL
Compound 401 is a potent inhibitor of DNA-PK (IC50=0
FLI-06 - Notch Pathway Modulator. CAS# 313967-18-9 Catalog No.:M60149-10S TA 02 and SB203580 reduceFLI 06, CAS No. 313967 18 9, is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2. 3 M), identified by using automated microscopy to monitor the trafficking and processing of a ligand independent Notch GFP fusion reporter. FLI 06 can induce accumulation of the reporter at the plasma membrane by interfering with transport in the secretory pathway. It can also disrupt the Golgi apparatus in