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PF-06647263 (anti-EFNA4-ADC) is generated via conjugation of hE22 lysine residues to the AcButDMH-N-Ac-calicheamicin-γ1 linker-payload with an average drug-to-antibody ratio (DAR) of 4
BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A
277(32):29294-303
CAS Number: 931398-72-0
CAS Number: 55981-09-4
Boc-C1-PEG3-C4-OBn sanib Diphosphate PF-06647263 (anti-EFNA4-ADC) is generated viaBoc C1 PEG3 C4 OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc C1 PEG3 C4 OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader 1 (HY 125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin proteasome system to selectively degrade target