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LX-7101 displays a significant IOP reduction at time points ranging from 1 h to 6 h post administration in rabbits
127(2):287-289
InChi: InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3
J147 was used at 1 µM in vitro and in cellular assays
6 nM in isolated rat lung and aorta
Zoledronic Acid Catalog No.:M9745-10 LX-7101 displays a significant IOPZoledronic acid is a synthetic imidazole bisphosphonate analog of pyrophosphate with anti bone resorption activity. A third generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the
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