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genetic and cell biology data point to Dyrk1a as the key molecular target
Bephenium is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis
The visualized decrease in megalin protein expression is confirmed by densitometry analyses
Selective inhibition of carboxylesterases by isatins
PubMed PMID: 21465936
TAK-063 Size:Solid 10 mg genetic and cell biology dataTAK 063, also known as Balipodect., is a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. TAK 063 is currently being evaluated in clinical trials for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is a cAMP cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. TAK 063 represents a promising drug for the treatment of schizophrenia with potential for superior safety
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