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InChiKey: ZGUSBCDCZNBNQT-UHFFFAOYSA-N
is a potent and selective inhibitor of KDM5 demethylases which reduces survival of drug-tolerant cancer cells
two of the most prominent Cdc42-mediated subcellular events
Erratum in: Nat Chem Biol
435(3):378-84
XAV939 - Wnt Antagonist. CAS# 284028-89-3 size:10mg solid InChiKey: ZGUSBCDCZNBNQT-UHFFFAOYSA-NXAV939, CAS No. 284028 89 3, is a potent and selective Wnt pathway antagonist. It functions to stabilize Axin by inhibiting the poly ADP ribosylating enzymes tankyrase 1 and tankyrase 2 with IC50 of 11 nM and 4 nM, respectively. It has been used to study Wnt dependent cancers. In addition, XAV939 was shown to stabilize Axin2 level in oligodendrocyte precursor cells in the spinal cord and accelerated their differentiation and myelination after hypoxic