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Wounds that have exposed blood vessels Wounds with exposed nerves, anastomotic sites, or organs Wounds, including open joint capsules Malignant wounds Wounds with necrotic tissue, it is recommended to excise first The following wounds could benefit from NPWT, but caution should be given (5): Wounds with a visible fistula Wounds with exposed bone or tendon The bone or tendon should be isolated from direct pressure Patients with clotting disorders or who are taking anticoagulants are at an increased risk of bleeding

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