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84(4):e475-81
InChiKey: OYVAGSVQBOHSSS-YRSNYMMHSA-O
Structure-activity relationship studies of small-molecule inhibitors of Wnt response
Cancer Chemother Pharmacol
a therapeutic agent
PRMT1-2e - Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor. CAS# 17328-16-4 279 84(4):e475-81PRMT1 2e, CAS No. 17328 16 4, is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 ~1. 5 M. It has no activity against CARM1 and Set7 9 methyltransferases. It inhibits growth of MCF7a breast cancer cells (IC50 ~1. 97 M) and LNCaP prostate cancer cells (IC50 ~4. 49 M). It can attenuate androgen induced gene expression in LNCaP cells. Product information CAS Number: 17328 16 4 Molecular Weight:
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